Seneca Vacation Rentals - HolidayHomes base64Hash Seneca Vacation Rentals - HolidayHomes

Seneca Vacation Rentals

Browse 251 available vacation homes and compared across 7 trusted partners

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Top-Rated Vacation rentals in Seneca

Book the highest-rated Seneca vacation rentals, rated by real guests for comfort, location, cleanliness, services and value for money

House Seneca

Vacation home with yard, barbeque & terrace | Lake view | Good for workation

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House Seneca

Family-friendly lovely house with BBQ, patio & hot tub | Lake view | Perfect for remote work | Pets are welcome

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House Seneca

House with terrace, BBQ & yard | Lake view | Perfect for remote work

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House Seneca

Vacation home with BBQ, patio & pool | Lake view

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House Seneca

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

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House Seneca

Secluded Seneca/Clemson Lake Hartwell Waterfront, 3 miles to CU

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House Seneca

Located on beautiful Lake Keowee

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House Seneca

Perfect Lake Hartwell Getaway - Gorgeous Lake Views!

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House Seneca

Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson

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House Seneca

Lakefront home with private beach & unbelievable sunsets on Lake Keowee

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House Seneca

Beautiful lakefront home in quiet cove, minutes from Clemson University.

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House Seneca

Keowee Adventures Peaceful Lakefront Home on Keowee 7 Miles from Clemson!

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House Seneca

Luxury on Lake Keowee - FALL & Summer 2027 NOW OPEN

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House Seneca

New to VRBO! Big water views, private dock, pool table, 15 min Clemson!

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House Seneca

Children-friendly lovely vacation home with terrace & grill | Nature view

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Top 15 most Recommended Vacation Rentals in Seneca

Discover your ideal Seneca vacation rental with real-time comparisons of 251 properties, featuring recommended options based on the property location, value for money, and verified guest reviews.

House Seneca
House ∙ 10 guests ∙ 3 bedrooms

Children-friendly charming vacation home with jacuzzi, grill & patio | Lake view

Seneca, Oconee County, South Carolina, United States
Spacious house rental in Seneca for 10 guests featuring a cozy fireplace and stunning lakeview for a perfect getaway.
from $575
per night
(63)
View deal
House Seneca
House ∙ 8 guests ∙ 4 bedrooms

Vacation home with patio, yard & BBQ

Seneca, Oconee County, South Carolina, United States
Spacious house rental in Seneca accommodating 10 guests, featuring a cozy fireplace for warm gatherings.
from $470
per night
(17)
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Cabin Seneca
Cabin ∙ 8 guests ∙ 3 bedrooms

Child-friendly ample cottage with terrace, barbecue & garden | Lake view | Perfect for remote work

Seneca, Oconee County, South Carolina, United States
This charming cabin in Seneca accommodates 8 guests and features a beautiful balcony for enjoying scenic views.
from $485
per night
(6)
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House Seneca
House ∙ 10 guests ∙ 3 bedrooms

House with 3 bedrooms for 10 persons

Seneca, Oconee County, South Carolina, United States
This spacious house rental in Seneca accommodates 10 guests and features a fully equipped kitchen for convenient meal prep.
from $374
per night
(19)
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House Seneca
House ∙ 8 guests ∙ 4 bedrooms

House with patio, hot tub & barbeque | Lake view | Good for workation

Seneca, Oconee County, South Carolina, United States
This house rental in Seneca accommodates 8 guests and features a beautiful lakeview balcony for relaxing evenings.
from $364
per night
(68)
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House Seneca
House ∙ 6 guests ∙ 3 bedrooms

Family-friendly house with yard, terrace & BBQ | Lake view | Suitable for remote work | Dogs allowed

Seneca, Oconee County, South Carolina, United States
This house rental in Seneca accommodates 6 guests and features a family-friendly kitchen perfect for gatherings.
from $150
per night
(19)
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House Seneca
House ∙ 6 guests ∙ 3 bedrooms

House with 3 bedrooms for 6 persons

Seneca, Oconee County, South Carolina, United States
This house rental in Seneca accommodates 6 guests and features a spacious backyard for outdoor relaxation.
from $221
per night
(34)
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Cabin Seneca
Cabin ∙ 6 guests ∙ 3 bedrooms

Cottage with pool & barbeque

Seneca, Oconee County, South Carolina, United States
This cozy cabin in Seneca accommodates 6 guests and features a welcoming fireplace for a warm retreat.
from $439
per night
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Cabin Seneca
Cabin ∙ 4 guests ∙ 2 bedrooms

Cottage with 2 bedrooms for 4 persons

Seneca, Oconee County, South Carolina, United States
This cozy cabin in Oconee County accommodates 4 guests and features convenient beach access for a perfect getaway.
from $257
per night
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